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The IND Application for 6MW3511 Injection - An Innovative Drug from Mabwell is Accepted by NMPA

Release time:Jun 17, 2022

Mabwell (stock code: 688062.SH), an innovative biopharmaceutical company with the layout of the whole industry chain, announced that the IND application for the self-developed 6MW3511 injection was accepted by China National Medical Products Administration (NMPA).

6MW3511 is a bifunctional group drug protein independently constructed by Mabwell using humanized anti-PD-L1 nanobodies to link to TGF-β RII mutants. The mutant design facilitates the maintenance of whole-molecule stability and reduces degradation of the natural TGF-β group during the manufacture process and in vivo. By blocking PD-1/PD-L1 and TGF-β/TGF-β-R dual pathways simultaneously, and with the excellent local tumor penetrability resulting from the concise structure, 6MW3511 is expected to further address the difficult problem of immunosuppression in the tumor microenvironment. The results of preclinical studies showed that 6MW3511 injection had good in vivo anti-tumor efficacy and good tolerability in animals. It is intended to be used clinically for the treatment of a variety of advanced solid tumors.

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